| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 10-12-21 22:15 | CA Platense | CA Velez Sarsfield | 3:2 |
| 11-12-21 0:30 | Estudiantes de La Plata | CA Aldosivi | 2:3 |
| 11-12-21 20:00 | Argentinos Juniors | CA Sarmiento Junin | 2:0 |
| 11-12-21 20:00 | Unión Santa Fé | Club Atlético Colón | 3:0 |
| 11-12-21 20:00 | Rosário Central | CA Huracán | 1:4 |
| 11-12-21 20:00 | Racing Club | CD Godoy Cruz | 2:1 |
| 11-12-21 20:00 | CA Patronato Paraná | Gimnasia y Esgrima La Plata | 0:0 |
| 11-12-21 22:15 | Atlético Tucumán | River Plate | 1:1 |
| 12-12-21 1:00 | Boca Juniors | Central Cordoba | 8:1 |
| 12-12-21 20:00 | CA San Lorenzo | Newell's Old Boys | 3:2 |
| 12-12-21 22:15 | Defensa y Justicia Florêncio Varela | CA Lanús | 2:1 |
| 13-12-21 0:30 | CA Talleres | Independiente | 1:2 |
| 13-12-21 23:00 | CA Banfield | Arsenal de Sarandi | 0:0 |