| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 08-05-21 17:00 | CD Godoy Cruz | CA Banfield | 0:1 |
| 08-05-21 19:30 | Gimnasia y Esgrima La Plata | CA Velez Sarsfield | 0:5 |
| 08-05-21 19:30 | Atlético Tucumán | Defensa y Justicia Florêncio Varela | 5:0 |
| 08-05-21 22:00 | CA Patronato Paraná | Boca Juniors | 1:0 |
| 09-05-21 14:00 | Arsenal de Sarandi | Central Cordoba | 1:1 |
| 09-05-21 16:10 | Argentinos Juniors | Estudiantes de La Plata | 2:0 |
| 09-05-21 18:30 | Racing Club | CA San Lorenzo | 2:0 |
| 09-05-21 18:30 | CA Platense | Rosário Central | 4:1 |
| 09-05-21 18:30 | River Plate | CA Aldosivi | 4:1 |
| 09-05-21 22:00 | CA Huracán | Independiente | 1:3 |
| 09-05-21 22:00 | CA Lanús | CA Talleres | 1:0 |
| 09-05-21 22:00 | Club Atlético Colón | Unión Santa Fé | 1:1 |
| 10-05-21 1:00 | Newell's Old Boys | CA Sarmiento Junin | 1:1 |