Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 14-05-22 14:30 | 14-05-22 14:30 | VfB Estugarda | 1. FC Colónia | 2:1 | 1 - 3 pontos |
| 14-05-22 14:30 | 14-05-22 14:30 | Bor. Mönchengladbach | 1899 Hoffenheim | 5:1 | 1 - 3 pontos |
| 14-05-22 14:30 | 14-05-22 14:30 | 1. FC Union Berlim | VfL Bochum | 3:2 | 1 - 3 pontos |
| 14-05-22 14:30 | 14-05-22 14:30 | Bayer 04 Leverkusen | SC Friburgo | 2:1 | 1 - 3 pontos |
| 14-05-22 14:30 | 14-05-22 14:30 | Borussia Dortmund | Hertha BSC Berlim | 2:1 | 1 - 3 pontos |
| 14-05-22 14:30 | 14-05-22 14:30 | Arminia Bielefeld | RB Leipzig | 1:1 | 1 - 3 pontos |
| 14-05-22 14:30 | 14-05-22 14:30 | FC Augsburg | SpVgg Greuther Fürth | 2:1 | 1 - 3 pontos |
| 14-05-22 14:30 | 14-05-22 14:30 | FSV Mainz 05 | Eintracht Frankfurt | 2:2 | 1 - 3 pontos |
| 14-05-22 14:35 | 14-05-22 14:35 | VfL Wolfsburgo | FC Bayern Munique | 2:2 | 1 - 3 pontos |