Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 01-10-21 19:30 | 01-10-21 19:30 | 1. FC Colónia | SpVgg Greuther Fürth | 3:1 | 1 - 3 pontos |
| 02-10-21 14:30 | 02-10-21 14:30 | Hertha BSC Berlim | SC Friburgo | 1:2 | 1 - 3 pontos |
| 02-10-21 14:30 | 02-10-21 14:30 | VfB Estugarda | 1899 Hoffenheim | 3:1 | 1 - 3 pontos |
| 02-10-21 14:30 | 02-10-21 14:30 | VfL Wolfsburgo | Bor. Mönchengladbach | 1:3 | 1 - 3 pontos |
| 02-10-21 14:30 | 02-10-21 14:30 | Borussia Dortmund | FC Augsburg | 2:1 | 1 - 3 pontos |
| 02-10-21 17:30 | 02-10-21 17:30 | RB Leipzig | VfL Bochum | 3:0 | 1 - 3 pontos |
| 03-10-21 14:30 | 03-10-21 14:30 | FSV Mainz 05 | 1. FC Union Berlim | 1:2 | 1 - 3 pontos |
| 03-10-21 16:30 | 03-10-21 16:30 | FC Bayern Munique | Eintracht Frankfurt | 1:2 | 1 - 3 pontos |
| 03-10-21 18:30 | 03-10-21 18:30 | Arminia Bielefeld | Bayer 04 Leverkusen | 0:4 | 1 - 3 pontos |