Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 16-04-22 14:30 | 16-04-22 14:30 | FC Augsburg | Hertha BSC Berlim | 0:1 | 1 - 3 pontos |
| 16-04-22 14:30 | 16-04-22 14:30 | FSV Mainz 05 | VfB Estugarda | 0:0 | 1 - 3 pontos |
| 16-04-22 14:30 | 16-04-22 14:30 | SC Friburgo | VfL Bochum | 3:0 | 1 - 3 pontos |
| 16-04-22 14:30 | 16-04-22 14:30 | Borussia Dortmund | VfL Wolfsburgo | 6:1 | 1 - 3 pontos |
| 16-04-22 17:30 | 16-04-22 17:30 | Bor. Mönchengladbach | 1. FC Colónia | 1:3 | 1 - 3 pontos |
| 17-04-22 14:30 | 17-04-22 14:30 | Arminia Bielefeld | FC Bayern Munique | 0:3 | 1 - 3 pontos |
| 17-04-22 16:30 | 17-04-22 16:30 | 1899 Hoffenheim | SpVgg Greuther Fürth | 0:0 | 1 - 3 pontos |
| 17-04-22 16:30 | 17-04-22 16:30 | 1. FC Union Berlim | Eintracht Frankfurt | 2:0 | 1 - 3 pontos |
| 17-04-22 18:30 | 17-04-22 18:30 | Bayer 04 Leverkusen | RB Leipzig | 0:1 | 1 - 3 pontos |