Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 08-04-22 19:30 | 08-04-22 19:30 | VfB Estugarda | Borussia Dortmund | 0:2 | 1 - 3 pontos |
| 09-04-22 14:30 | 09-04-22 14:30 | 1. FC Colónia | FSV Mainz 05 | 3:2 | 1 - 3 pontos |
| 09-04-22 14:30 | 09-04-22 14:30 | VfL Wolfsburgo | Arminia Bielefeld | 4:0 | 1 - 3 pontos |
| 09-04-22 14:30 | 09-04-22 14:30 | FC Bayern Munique | FC Augsburg | 1:0 | 1 - 3 pontos |
| 09-04-22 14:30 | 09-04-22 14:30 | SpVgg Greuther Fürth | Bor. Mönchengladbach | 0:2 | 1 - 3 pontos |
| 09-04-22 17:30 | 09-04-22 17:30 | Hertha BSC Berlim | 1. FC Union Berlim | 1:4 | 1 - 3 pontos |
| 10-04-22 14:30 | 10-04-22 14:30 | VfL Bochum | Bayer 04 Leverkusen | 0:0 | 1 - 3 pontos |
| 10-04-22 16:30 | 10-04-22 16:30 | Eintracht Frankfurt | SC Friburgo | 1:2 | 1 - 3 pontos |
| 10-04-22 18:30 | 10-04-22 18:30 | RB Leipzig | 1899 Hoffenheim | 3:0 | 1 - 3 pontos |