Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 04-03-22 19:30 | 04-03-22 19:30 | Arminia Bielefeld | FC Augsburg | 0:1 | 1 - 3 pontos |
| 05-03-22 14:30 | 05-03-22 14:30 | Hertha BSC Berlim | Eintracht Frankfurt | 1:4 | 1 - 3 pontos |
| 05-03-22 14:30 | 05-03-22 14:30 | FC Bayern Munique | Bayer 04 Leverkusen | 1:1 | 1 - 3 pontos |
| 05-03-22 14:30 | 05-03-22 14:30 | VfL Wolfsburgo | 1. FC Union Berlim | 1:0 | 1 - 3 pontos |
| 05-03-22 14:30 | 05-03-22 14:30 | RB Leipzig | SC Friburgo | 1:1 | 1 - 3 pontos |
| 05-03-22 14:30 | 05-03-22 14:30 | VfL Bochum | SpVgg Greuther Fürth | 2:1 | 1 - 3 pontos |
| 05-03-22 17:30 | 05-03-22 17:30 | VfB Estugarda | Bor. Mönchengladbach | 3:2 | 1 - 3 pontos |
| 06-03-22 16:30 | 06-03-22 16:30 | 1. FC Colónia | 1899 Hoffenheim | 0:1 | 1 - 3 pontos |
| 16-03-22 17:30 | 16-03-22 17:30 | FSV Mainz 05 | Borussia Dortmund | 0:1 | 1 - 3 pontos |