Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 03-12-21 19:30 | 03-12-21 19:30 | 1. FC Union Berlim | RB Leipzig | 2:1 | 1 - 3 pontos |
| 04-12-21 14:30 | 04-12-21 14:30 | FSV Mainz 05 | VfL Wolfsburgo | 3:0 | 1 - 3 pontos |
| 04-12-21 14:30 | 04-12-21 14:30 | 1899 Hoffenheim | Eintracht Frankfurt | 3:2 | 1 - 3 pontos |
| 04-12-21 14:30 | 04-12-21 14:30 | Bayer 04 Leverkusen | SpVgg Greuther Fürth | 7:1 | 1 - 3 pontos |
| 04-12-21 14:30 | 04-12-21 14:30 | Arminia Bielefeld | 1. FC Colónia | 1:1 | 1 - 3 pontos |
| 04-12-21 14:30 | 04-12-21 14:30 | FC Augsburg | VfL Bochum | 2:3 | 1 - 3 pontos |
| 04-12-21 17:30 | 04-12-21 17:30 | Borussia Dortmund | FC Bayern Munique | 2:3 | 1 - 3 pontos |
| 05-12-21 14:30 | 05-12-21 14:30 | VfB Estugarda | Hertha BSC Berlim | 2:2 | 1 - 3 pontos |
| 05-12-21 16:30 | 05-12-21 16:30 | Bor. Mönchengladbach | SC Friburgo | 0:6 | 1 - 3 pontos |