| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 27-05-22 20:00 | Real Sociedad B | Real Zaragoza | 1:2 |
| 27-05-22 20:00 | CD Mirandés | CF Fuenlabrada | 5:1 |
| 28-05-22 17:15 | SD Amorebieta | SD Ponferradina | 1:0 |
| 28-05-22 17:15 | CD Lugo | FC Málaga | 1:0 |
| 29-05-22 19:00 | Burgos CF | FC Girona | 0:0 |
| 29-05-22 19:00 | CD Leganés | UD Almeria | 2:2 |
| 29-05-22 19:00 | Real Oviedo | UD Ibiza Eivissa | 3:2 |
| 29-05-22 19:00 | Sporting Gijón | UD Las Palmas | 0:1 |
| 29-05-22 19:00 | AD Alcorcón | SD Eibar | 1:0 |
| 29-05-22 19:00 | CD Teneriffa | FC Cartagena | 1:2 |
| 29-05-22 19:00 | Real Valladolid | SD Huesca | 3:0 |