| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 16-05-21 13:30 | PEC Zwolle | FC Groningen | 1:0 |
| 16-05-21 13:30 | VVV Venlo | FC Emmen | 0:4 |
| 16-05-21 13:30 | AZ Alkmaar | Heracles Almelo | 5:0 |
| 16-05-21 13:30 | SC Heerenveen | Sparta Roterdão | 1:2 |
| 16-05-21 13:30 | FC Utrecht | PSV Eindhoven | 1:1 |
| 16-05-21 13:30 | FC Twente Enschede | ADO Den Haag | 3:2 |
| 16-05-21 13:30 | Feyenoord Rotterdão | RKC Waalwijk | 3:0 |
| 16-05-21 13:30 | Willem II Tilburg | Fortuna Sittard | 2:1 |
| 16-05-21 13:30 | Vitesse Arnheim | Ajax Amsterdão | 1:3 |