| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 21-05-22 20:00 | OSC Lille | Stade Rennes | 2:2 |
| 21-05-22 20:00 | FC Lorient | ES Troyes AC | 1:1 |
| 21-05-22 20:00 | Olympique Marselha | Racing Club Estrasburgo | 4:0 |
| 21-05-22 20:00 | FC Nantes | AS St. Etienne | 1:1 |
| 21-05-22 20:00 | Paris St. Germain | FC Metz | 5:0 |
| 21-05-22 20:00 | Stade Reims | OGC Nice | 2:3 |
| 21-05-22 20:00 | SCO Angers | HSC Montpellier | 2:0 |
| 21-05-22 20:00 | Stade Brest 29 | Girondins Bordeaux | 2:4 |
| 21-05-22 20:00 | Clermont Foot | Olympique Lyon | 1:2 |
| 21-05-22 20:00 | RC Lens | AS Mónaco | 2:2 |