| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 15-10-21 19:30 | 15-10-21 19:30 | 1899 Hoffenheim | 1. FC Colónia | 5:0 | 3 - 5 pontos |
| 16-10-21 14:30 | 16-10-21 14:30 | 1. FC Union Berlim | VfL Wolfsburgo | 2:0 | 3 - 5 pontos |
| 16-10-21 14:30 | 16-10-21 14:30 | Eintracht Frankfurt | Hertha BSC Berlim | 1:2 | 3 - 5 pontos |
| 16-10-21 14:30 | 16-10-21 14:30 | Borussia Dortmund | FSV Mainz 05 | 3:1 | 3 - 5 pontos |
| 16-10-21 14:30 | 16-10-21 14:30 | SpVgg Greuther Fürth | VfL Bochum | 0:1 | 3 - 5 pontos |
| 16-10-21 14:30 | 16-10-21 14:30 | SC Friburgo | RB Leipzig | 1:1 | 3 - 5 pontos |
| 16-10-21 17:30 | 16-10-21 17:30 | Bor. Mönchengladbach | VfB Estugarda | 1:1 | 3 - 5 pontos |
| 17-10-21 14:30 | 17-10-21 14:30 | Bayer 04 Leverkusen | FC Bayern Munique | 1:5 | 3 - 5 pontos |
| 17-10-21 16:30 | 17-10-21 16:30 | FC Augsburg | Arminia Bielefeld | 1:1 | 3 - 5 pontos |