| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 29-10-21 19:30 | 29-10-21 19:30 | 1899 Hoffenheim | Hertha BSC Berlim | 2:0 | 3 - 5 pontos |
| 30-10-21 14:30 | 30-10-21 14:30 | Arminia Bielefeld | FSV Mainz 05 | 1:2 | 3 - 5 pontos |
| 30-10-21 14:30 | 30-10-21 14:30 | SC Friburgo | SpVgg Greuther Fürth | 3:1 | 3 - 5 pontos |
| 30-10-21 14:30 | 30-10-21 14:30 | 1. FC Union Berlim | FC Bayern Munique | 2:5 | 3 - 5 pontos |
| 30-10-21 14:30 | 30-10-21 14:30 | Bayer 04 Leverkusen | VfL Wolfsburgo | 0:2 | 3 - 5 pontos |
| 30-10-21 14:30 | 30-10-21 14:30 | Borussia Dortmund | 1. FC Colónia | 2:0 | 3 - 5 pontos |
| 30-10-21 17:30 | 30-10-21 17:30 | Eintracht Frankfurt | RB Leipzig | 1:1 | 3 - 5 pontos |
| 31-10-21 14:30 | 31-10-21 14:30 | FC Augsburg | VfB Estugarda | 4:1 | 3 - 5 pontos |
| 31-10-21 16:30 | 31-10-21 16:30 | Bor. Mönchengladbach | VfL Bochum | 2:1 | 3 - 5 pontos |