| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|
| 29-04-22 19:30 | 29-04-22 19:00 | 1. FC Union Berlim | SpVgg Greuther Fürth | 1:1 | 2 - 4 pontos |
| 30-04-22 14:30 | 30-04-22 14:00 | Arminia Bielefeld | Hertha BSC Berlim | 1:1 | 2 - 4 pontos |
| 30-04-22 14:30 | 30-04-22 14:00 | FC Augsburg | 1. FC Colónia | 1:4 | 2 - 4 pontos |
| 30-04-22 14:30 | 30-04-22 14:00 | FSV Mainz 05 | FC Bayern Munique | 3:1 | 2 - 4 pontos |
| 30-04-22 14:30 | 30-04-22 14:00 | VfB Estugarda | VfL Wolfsburgo | 1:1 | 2 - 4 pontos |
| 30-04-22 14:30 | 30-04-22 14:00 | Borussia Dortmund | VfL Bochum | 3:4 | 2 - 4 pontos |
| 30-04-22 17:30 | 30-04-22 17:00 | 1899 Hoffenheim | SC Friburgo | 3:4 | 2 - 4 pontos |
| 02-05-22 19:30 | 02-05-22 19:00 | Bor. Mönchengladbach | RB Leipzig | 3:1 | 2 - 4 pontos |
| 02-05-22 19:30 | 02-05-22 19:00 | Bayer 04 Leverkusen | Eintracht Frankfurt | 2:0 | 2 - 4 pontos |
