| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|
| 01-04-22 19:30 | 01-04-22 19:00 | 1. FC Union Berlim | 1. FC Colónia | 1:0 | 2 - 4 pontos |
| 02-04-22 14:30 | 02-04-22 14:00 | Eintracht Frankfurt | SpVgg Greuther Fürth | 0:0 | 2 - 4 pontos |
| 02-04-22 14:30 | 02-04-22 14:00 | Arminia Bielefeld | VfB Estugarda | 1:1 | 2 - 4 pontos |
| 02-04-22 14:30 | 02-04-22 14:00 | 1899 Hoffenheim | VfL Bochum | 1:2 | 2 - 4 pontos |
| 02-04-22 14:30 | 02-04-22 14:00 | SC Friburgo | FC Bayern Munique | 1:4 | 2 - 4 pontos |
| 02-04-22 14:30 | 02-04-22 14:00 | Bayer 04 Leverkusen | Hertha BSC Berlim | 2:1 | 2 - 4 pontos |
| 02-04-22 17:30 | 02-04-22 17:00 | Borussia Dortmund | RB Leipzig | 1:4 | 2 - 4 pontos |
| 03-04-22 14:30 | 03-04-22 14:00 | FC Augsburg | VfL Wolfsburgo | 3:0 | 2 - 4 pontos |
| 03-04-22 16:30 | 03-04-22 16:00 | Bor. Mönchengladbach | FSV Mainz 05 | 1:1 | 2 - 4 pontos |
