| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|
| 05-11-21 19:30 | 05-11-21 19:00 | FSV Mainz 05 | Bor. Mönchengladbach | 1:1 | 2 - 4 pontos |
| 06-11-21 14:30 | 06-11-21 14:00 | VfB Estugarda | Arminia Bielefeld | 0:1 | 2 - 4 pontos |
| 06-11-21 14:30 | 06-11-21 14:00 | VfL Wolfsburgo | FC Augsburg | 1:0 | 2 - 4 pontos |
| 06-11-21 14:30 | 06-11-21 14:00 | FC Bayern Munique | SC Friburgo | 2:1 | 2 - 4 pontos |
| 06-11-21 14:30 | 06-11-21 14:00 | VfL Bochum | 1899 Hoffenheim | 2:0 | 2 - 4 pontos |
| 06-11-21 17:30 | 06-11-21 17:00 | RB Leipzig | Borussia Dortmund | 2:1 | 2 - 4 pontos |
| 07-11-21 14:30 | 07-11-21 14:00 | Hertha BSC Berlim | Bayer 04 Leverkusen | 1:1 | 2 - 4 pontos |
| 07-11-21 16:30 | 07-11-21 16:00 | 1. FC Colónia | 1. FC Union Berlim | 2:2 | 2 - 4 pontos |
| 07-11-21 18:30 | 07-11-21 18:00 | SpVgg Greuther Fürth | Eintracht Frankfurt | 1:2 | 2 - 4 pontos |
