Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 26-11-21 19:30 | 26-11-21 19:29 | VfB Estugarda | FSV Mainz 05 | 2:1 | 2 - 4 pontos |
| 27-11-21 14:30 | 27-11-21 14:29 | 1. FC Colónia | Bor. Mönchengladbach | 4:1 | 2 - 4 pontos |
| 27-11-21 14:30 | 27-11-21 14:29 | Hertha BSC Berlim | FC Augsburg | 1:1 | 2 - 4 pontos |
| 27-11-21 14:30 | 27-11-21 14:29 | VfL Wolfsburgo | Borussia Dortmund | 1:3 | 2 - 4 pontos |
| 27-11-21 14:30 | 27-11-21 14:29 | SpVgg Greuther Fürth | 1899 Hoffenheim | 3:6 | 2 - 4 pontos |
| 27-11-21 14:30 | 27-11-21 14:29 | VfL Bochum | SC Friburgo | 2:1 | 2 - 4 pontos |
| 27-11-21 17:30 | 27-11-21 17:29 | FC Bayern Munique | Arminia Bielefeld | 1:0 | 2 - 4 pontos |
| 28-11-21 14:30 | 28-11-21 14:29 | Eintracht Frankfurt | 1. FC Union Berlim | 2:1 | 2 - 4 pontos |
| 28-11-21 16:30 | 28-11-21 16:29 | RB Leipzig | Bayer 04 Leverkusen | 1:3 | 2 - 4 pontos |