Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 01-10-21 17:30 | 01-10-21 17:30 | Werder Bremen | 1. FC Heidenheim 1846 | 3:0 | 2 - 4 pontos |
| 01-10-21 17:30 | 01-10-21 17:30 | Erzgebirge Aue | Hamburgo SV | 1:1 | 2 - 4 pontos |
| 02-10-21 12:30 | 02-10-21 12:30 | Holstein Kiel | FC Hansa Rostock | 0:2 | 2 - 4 pontos |
| 02-10-21 12:30 | 02-10-21 12:30 | Fortuna Düsseldorf | SC Paderborn 07 | 2:3 | 2 - 4 pontos |
| 02-10-21 12:30 | 02-10-21 12:30 | Jahn Regensburg | Karlsruher SC | 2:2 | 2 - 4 pontos |
| 02-10-21 19:30 | 02-10-21 19:30 | 1. FC Nuremberga | Hannover 96 | 0:0 | 2 - 4 pontos |
| 03-10-21 12:30 | 03-10-21 12:30 | SV Sandhausen | SV Darmstadt 98 | 1:6 | 2 - 4 pontos |
| 03-10-21 12:30 | 03-10-21 12:30 | FC Schalke 04 | FC Ingolstadt | 3:0 | 2 - 4 pontos |
| 03-10-21 12:30 | 03-10-21 12:30 | FC St. Pauli | Dynamo Dresden | 3:0 | 2 - 4 pontos |