Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 29-04-22 17:30 | 29-04-22 17:30 | 1. FC Heidenheim 1846 | Fortuna Düsseldorf | 1:3 | 2 - 4 pontos |
| 29-04-22 17:30 | 29-04-22 17:30 | FC St. Pauli | 1. FC Nuremberga | 1:1 | 2 - 4 pontos |
| 29-04-22 17:30 | 29-04-22 17:30 | Hannover 96 | Karlsruher SC | 2:0 | 2 - 4 pontos |
| 29-04-22 17:30 | 29-04-22 17:30 | SV Sandhausen | FC Schalke 04 | 1:2 | 2 - 4 pontos |
| 29-04-22 17:30 | 29-04-22 17:30 | Werder Bremen | Holstein Kiel | 2:3 | 2 - 4 pontos |
| 30-04-22 12:30 | 30-04-22 12:30 | Dynamo Dresden | Jahn Regensburg | 1:1 | 2 - 4 pontos |
| 30-04-22 12:30 | 30-04-22 12:30 | FC Hansa Rostock | SC Paderborn 07 | 0:0 | 2 - 4 pontos |
| 30-04-22 12:30 | 30-04-22 12:30 | FC Ingolstadt | Hamburgo SV | 0:4 | 2 - 4 pontos |
| 30-04-22 19:30 | 30-04-22 19:30 | SV Darmstadt 98 | Erzgebirge Aue | 6:0 | 2 - 4 pontos |