Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 22-04-22 17:30 | 22-04-22 17:30 | Fortuna Düsseldorf | Dynamo Dresden | 2:2 | 2 - 4 pontos |
| 22-04-22 17:30 | 22-04-22 17:30 | Karlsruher SC | FC Ingolstadt | 2:2 | 2 - 4 pontos |
| 23-04-22 12:30 | 23-04-22 12:30 | FC Schalke 04 | Werder Bremen | 1:4 | 2 - 4 pontos |
| 23-04-22 12:30 | 23-04-22 12:30 | Holstein Kiel | 1. FC Heidenheim 1846 | 1:1 | 2 - 4 pontos |
| 23-04-22 12:30 | 23-04-22 12:30 | Jahn Regensburg | Hamburgo SV | 2:4 | 2 - 4 pontos |
| 23-04-22 19:30 | 23-04-22 19:30 | FC St. Pauli | SV Darmstadt 98 | 1:2 | 2 - 4 pontos |
| 24-04-22 12:30 | 24-04-22 12:30 | SC Paderborn 07 | Hannover 96 | 3:0 | 2 - 4 pontos |
| 24-04-22 12:30 | 24-04-22 12:30 | 1. FC Nuremberga | SV Sandhausen | 2:4 | 2 - 4 pontos |
| 24-04-22 12:30 | 24-04-22 12:30 | Erzgebirge Aue | FC Hansa Rostock | 2:2 | 2 - 4 pontos |