Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 16-04-22 12:30 | 16-04-22 12:30 | Hannover 96 | Fortuna Düsseldorf | 0:0 | 2 - 4 pontos |
| 16-04-22 12:30 | 16-04-22 12:30 | SV Sandhausen | FC St. Pauli | 1:1 | 2 - 4 pontos |
| 16-04-22 12:30 | 16-04-22 12:30 | Dynamo Dresden | Holstein Kiel | 0:0 | 2 - 4 pontos |
| 16-04-22 19:30 | 16-04-22 19:30 | Hamburgo SV | Karlsruher SC | 3:0 | 2 - 4 pontos |
| 17-04-22 12:30 | 17-04-22 12:30 | FC Hansa Rostock | Jahn Regensburg | 1:1 | 2 - 4 pontos |
| 17-04-22 12:30 | 17-04-22 12:30 | FC Ingolstadt | SC Paderborn 07 | 0:1 | 2 - 4 pontos |
| 17-04-22 12:30 | 17-04-22 12:30 | Werder Bremen | 1. FC Nuremberga | 1:1 | 2 - 4 pontos |
| 17-04-22 12:30 | 17-04-22 12:30 | SV Darmstadt 98 | FC Schalke 04 | 2:5 | 2 - 4 pontos |
| 17-04-22 12:30 | 17-04-22 12:30 | 1. FC Heidenheim 1846 | Erzgebirge Aue | 0:2 | 2 - 4 pontos |