Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 13-08-21 17:30 | 13-08-21 17:30 | FC Schalke 04 | Erzgebirge Aue | 1:1 | 2 - 4 pontos |
| 13-08-21 17:30 | 13-08-21 17:30 | FC St. Pauli | Hamburgo SV | 3:2 | 2 - 4 pontos |
| 14-08-21 12:30 | 14-08-21 12:30 | Holstein Kiel | Jahn Regensburg | 0:3 | 2 - 4 pontos |
| 14-08-21 12:30 | 14-08-21 12:30 | 1. FC Nuremberga | Fortuna Düsseldorf | 2:0 | 2 - 4 pontos |
| 14-08-21 12:30 | 14-08-21 12:30 | SV Sandhausen | Karlsruher SC | 0:0 | 2 - 4 pontos |
| 14-08-21 19:30 | 14-08-21 19:30 | Dynamo Dresden | Hannover 96 | 2:0 | 2 - 4 pontos |
| 15-08-21 12:30 | 15-08-21 12:30 | Werder Bremen | SC Paderborn 07 | 1:4 | 2 - 4 pontos |
| 15-08-21 12:30 | 15-08-21 12:30 | SV Darmstadt 98 | FC Ingolstadt | 6:1 | 2 - 4 pontos |
| 15-08-21 12:30 | 15-08-21 12:30 | 1. FC Heidenheim 1846 | FC Hansa Rostock | 1:1 | 2 - 4 pontos |