Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 08-04-22 17:30 | 08-04-22 17:30 | Jahn Regensburg | FC Ingolstadt | 1:1 | 2 - 4 pontos |
| 08-04-22 17:30 | 08-04-22 17:30 | Fortuna Düsseldorf | FC Hansa Rostock | 3:0 | 2 - 4 pontos |
| 09-04-22 12:30 | 09-04-22 12:30 | Erzgebirge Aue | Hannover 96 | 1:3 | 2 - 4 pontos |
| 09-04-22 12:30 | 09-04-22 12:30 | FC Schalke 04 | 1. FC Heidenheim 1846 | 3:0 | 2 - 4 pontos |
| 09-04-22 12:30 | 09-04-22 12:30 | FC St. Pauli | Werder Bremen | 1:1 | 2 - 4 pontos |
| 09-04-22 19:30 | 09-04-22 19:30 | 1. FC Nuremberga | SV Darmstadt 98 | 3:1 | 2 - 4 pontos |
| 10-04-22 12:30 | 10-04-22 12:30 | SV Sandhausen | Dynamo Dresden | 2:1 | 2 - 4 pontos |
| 10-04-22 12:30 | 10-04-22 12:30 | Holstein Kiel | Hamburgo SV | 1:0 | 2 - 4 pontos |
| 10-04-22 12:30 | 10-04-22 12:30 | SC Paderborn 07 | Karlsruher SC | 2:2 | 2 - 4 pontos |