Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 01-04-22 17:30 | 01-04-22 17:30 | Dynamo Dresden | FC Schalke 04 | 1:2 | 2 - 4 pontos |
| 01-04-22 17:30 | 01-04-22 17:30 | FC Ingolstadt | Erzgebirge Aue | 3:2 | 2 - 4 pontos |
| 02-04-22 12:30 | 02-04-22 12:30 | Hamburgo SV | SC Paderborn 07 | 1:2 | 2 - 4 pontos |
| 02-04-22 12:30 | 02-04-22 12:30 | SV Darmstadt 98 | Holstein Kiel | 3:1 | 2 - 4 pontos |
| 02-04-22 12:30 | 02-04-22 12:30 | Hannover 96 | Jahn Regensburg | 1:1 | 2 - 4 pontos |
| 02-04-22 19:30 | 02-04-22 19:30 | FC Hansa Rostock | FC St. Pauli | 1:0 | 2 - 4 pontos |
| 03-04-22 12:30 | 03-04-22 12:30 | Werder Bremen | SV Sandhausen | 1:1 | 2 - 4 pontos |
| 03-04-22 12:30 | 03-04-22 12:30 | Karlsruher SC | Fortuna Düsseldorf | 2:2 | 2 - 4 pontos |
| 03-04-22 12:30 | 03-04-22 12:30 | 1. FC Heidenheim 1846 | 1. FC Nuremberga | 3:1 | 2 - 4 pontos |