Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 04-03-22 17:30 | 04-03-22 17:30 | SV Darmstadt 98 | 1. FC Heidenheim 1846 | 3:2 | 2 - 4 pontos |
| 04-03-22 17:30 | 04-03-22 17:30 | Holstein Kiel | SC Paderborn 07 | 3:4 | 2 - 4 pontos |
| 05-03-22 12:30 | 05-03-22 12:30 | FC St. Pauli | Karlsruher SC | 3:1 | 2 - 4 pontos |
| 05-03-22 12:30 | 05-03-22 12:30 | SV Sandhausen | Hannover 96 | 3:1 | 2 - 4 pontos |
| 05-03-22 12:30 | 05-03-22 12:30 | FC Schalke 04 | FC Hansa Rostock | 3:4 | 2 - 4 pontos |
| 05-03-22 19:30 | 05-03-22 19:30 | 1. FC Nuremberga | Hamburgo SV | 2:1 | 2 - 4 pontos |
| 06-03-22 12:30 | 06-03-22 12:30 | Erzgebirge Aue | Jahn Regensburg | 1:0 | 2 - 4 pontos |
| 06-03-22 12:30 | 06-03-22 12:30 | Werder Bremen | Dynamo Dresden | 2:1 | 2 - 4 pontos |
| 06-03-22 12:30 | 06-03-22 12:30 | Fortuna Düsseldorf | FC Ingolstadt | 3:0 | 2 - 4 pontos |