Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 04-02-22 17:30 | 04-02-22 17:30 | 1. FC Heidenheim 1846 | Hannover 96 | 3:1 | 2 - 4 pontos |
| 04-02-22 17:30 | 04-02-22 17:30 | 1. FC Nuremberga | FC Ingolstadt | 0:5 | 2 - 4 pontos |
| 05-02-22 12:30 | 05-02-22 12:30 | SV Sandhausen | Erzgebirge Aue | 2:0 | 2 - 4 pontos |
| 05-02-22 12:30 | 05-02-22 12:30 | Werder Bremen | Karlsruher SC | 2:1 | 2 - 4 pontos |
| 05-02-22 12:30 | 05-02-22 12:30 | FC Schalke 04 | Jahn Regensburg | 2:1 | 2 - 4 pontos |
| 05-02-22 19:30 | 05-02-22 19:30 | FC St. Pauli | SC Paderborn 07 | 2:2 | 2 - 4 pontos |
| 06-02-22 12:30 | 06-02-22 12:30 | SV Darmstadt 98 | Hamburgo SV | 0:5 | 2 - 4 pontos |
| 06-02-22 12:30 | 06-02-22 12:30 | Dynamo Dresden | FC Hansa Rostock | 1:4 | 2 - 4 pontos |
| 06-02-22 12:30 | 06-02-22 12:30 | Holstein Kiel | Fortuna Düsseldorf | 1:0 | 2 - 4 pontos |