Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 21-01-22 17:30 | 21-01-22 17:30 | Hamburgo SV | FC St. Pauli | 2:1 | 2 - 4 pontos |
| 21-01-22 17:30 | 21-01-22 17:30 | Fortuna Düsseldorf | 1. FC Nuremberga | 0:1 | 2 - 4 pontos |
| 22-01-22 12:30 | 22-01-22 12:30 | FC Ingolstadt | SV Darmstadt 98 | 0:2 | 2 - 4 pontos |
| 22-01-22 12:30 | 22-01-22 12:30 | SC Paderborn 07 | Werder Bremen | 3:4 | 2 - 4 pontos |
| 22-01-22 12:30 | 22-01-22 12:30 | FC Hansa Rostock | 1. FC Heidenheim 1846 | 0:0 | 2 - 4 pontos |
| 22-01-22 19:30 | 22-01-22 19:30 | Erzgebirge Aue | FC Schalke 04 | 0:5 | 2 - 4 pontos |
| 23-01-22 12:30 | 23-01-22 12:30 | Hannover 96 | Dynamo Dresden | 0:0 | 2 - 4 pontos |
| 23-01-22 12:30 | 23-01-22 12:30 | Jahn Regensburg | Holstein Kiel | 1:2 | 2 - 4 pontos |
| 08-02-22 17:30 | 08-02-22 17:30 | Karlsruher SC | SV Sandhausen | 0:2 | 2 - 4 pontos |