Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 14-01-22 17:30 | 14-01-22 17:30 | FC Hansa Rostock | Hannover 96 | 0:1 | 2 - 4 pontos |
| 14-01-22 17:30 | 14-01-22 17:30 | Dynamo Dresden | Hamburgo SV | 1:1 | 2 - 4 pontos |
| 15-01-22 12:30 | 15-01-22 12:30 | Werder Bremen | Fortuna Düsseldorf | 3:0 | 2 - 4 pontos |
| 15-01-22 12:30 | 15-01-22 12:30 | FC St. Pauli | Erzgebirge Aue | 2:2 | 2 - 4 pontos |
| 15-01-22 12:30 | 15-01-22 12:30 | 1. FC Nuremberga | SC Paderborn 07 | 1:2 | 2 - 4 pontos |
| 15-01-22 19:30 | 15-01-22 19:30 | SV Darmstadt 98 | Karlsruher SC | 2:2 | 2 - 4 pontos |
| 16-01-22 12:30 | 16-01-22 12:30 | FC Schalke 04 | Holstein Kiel | 1:1 | 2 - 4 pontos |
| 16-01-22 12:30 | 16-01-22 12:30 | 1. FC Heidenheim 1846 | FC Ingolstadt | 2:1 | 2 - 4 pontos |
| 16-01-22 12:30 | 16-01-22 12:30 | SV Sandhausen | Jahn Regensburg | 0:3 | 2 - 4 pontos |