Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 17-12-21 17:30 | 17-12-21 17:30 | Fortuna Düsseldorf | SV Sandhausen | 0:1 | 2 - 4 pontos |
| 17-12-21 17:30 | 17-12-21 17:30 | Holstein Kiel | FC St. Pauli | 3:0 | 2 - 4 pontos |
| 18-12-21 12:30 | 18-12-21 12:30 | SC Paderborn 07 | 1. FC Heidenheim 1846 | 1:2 | 2 - 4 pontos |
| 18-12-21 12:30 | 18-12-21 12:30 | Erzgebirge Aue | 1. FC Nuremberga | 1:3 | 2 - 4 pontos |
| 18-12-21 12:30 | 18-12-21 12:30 | FC Ingolstadt | Dynamo Dresden | 3:0 | 2 - 4 pontos |
| 18-12-21 19:30 | 18-12-21 19:30 | Hamburgo SV | FC Schalke 04 | 1:1 | 2 - 4 pontos |
| 19-12-21 12:30 | 19-12-21 12:30 | Karlsruher SC | FC Hansa Rostock | 2:2 | 2 - 4 pontos |
| 19-12-21 12:30 | 19-12-21 12:30 | Hannover 96 | Werder Bremen | 1:4 | 2 - 4 pontos |
| 19-12-21 12:30 | 19-12-21 12:30 | Jahn Regensburg | SV Darmstadt 98 | 0:2 | 2 - 4 pontos |