Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 03-12-21 17:30 | 03-12-21 17:30 | Werder Bremen | Erzgebirge Aue | 4:0 | 2 - 4 pontos |
| 03-12-21 17:30 | 03-12-21 17:30 | SV Darmstadt 98 | Fortuna Düsseldorf | 1:3 | 2 - 4 pontos |
| 04-12-21 12:30 | 04-12-21 12:30 | 1. FC Nuremberga | Holstein Kiel | 2:1 | 2 - 4 pontos |
| 04-12-21 12:30 | 04-12-21 12:30 | SV Sandhausen | SC Paderborn 07 | 1:1 | 2 - 4 pontos |
| 04-12-21 12:30 | 04-12-21 12:30 | FC Hansa Rostock | FC Ingolstadt | 1:1 | 2 - 4 pontos |
| 04-12-21 19:30 | 04-12-21 19:30 | FC St. Pauli | FC Schalke 04 | 2:1 | 2 - 4 pontos |
| 05-12-21 12:30 | 05-12-21 12:30 | Hannover 96 | Hamburgo SV | 1:0 | 2 - 4 pontos |
| 05-12-21 12:30 | 05-12-21 12:30 | Dynamo Dresden | Karlsruher SC | 3:1 | 2 - 4 pontos |
| 05-12-21 12:30 | 05-12-21 12:30 | 1. FC Heidenheim 1846 | Jahn Regensburg | 3:0 | 2 - 4 pontos |