Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 26-11-21 17:30 | 26-11-21 17:30 | Jahn Regensburg | Dynamo Dresden | 3:1 | 2 - 4 pontos |
| 26-11-21 17:30 | 26-11-21 17:30 | Fortuna Düsseldorf | 1. FC Heidenheim 1846 | 0:1 | 2 - 4 pontos |
| 27-11-21 12:30 | 27-11-21 12:30 | Karlsruher SC | Hannover 96 | 4:0 | 2 - 4 pontos |
| 27-11-21 12:30 | 27-11-21 12:30 | Erzgebirge Aue | SV Darmstadt 98 | 1:2 | 2 - 4 pontos |
| 27-11-21 12:30 | 27-11-21 12:30 | FC Schalke 04 | SV Sandhausen | 5:2 | 2 - 4 pontos |
| 27-11-21 19:30 | 27-11-21 19:30 | Holstein Kiel | Werder Bremen | 2:1 | 2 - 4 pontos |
| 28-11-21 12:30 | 28-11-21 12:30 | SC Paderborn 07 | FC Hansa Rostock | 1:1 | 2 - 4 pontos |
| 28-11-21 12:30 | 28-11-21 12:30 | 1. FC Nuremberga | FC St. Pauli | 2:3 | 2 - 4 pontos |
| 28-11-21 12:30 | 28-11-21 12:30 | Hamburgo SV | FC Ingolstadt | 3:0 | 2 - 4 pontos |