Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 05-11-21 17:30 | 05-11-21 17:30 | Holstein Kiel | Dynamo Dresden | 2:1 | 2 - 4 pontos |
| 05-11-21 17:30 | 05-11-21 17:30 | 1. FC Nuremberga | Werder Bremen | 1:2 | 2 - 4 pontos |
| 06-11-21 12:30 | 06-11-21 12:30 | Fortuna Düsseldorf | Hannover 96 | 1:1 | 2 - 4 pontos |
| 06-11-21 12:30 | 06-11-21 12:30 | SC Paderborn 07 | FC Ingolstadt | 2:1 | 2 - 4 pontos |
| 06-11-21 12:30 | 06-11-21 12:30 | Jahn Regensburg | FC Hansa Rostock | 2:3 | 2 - 4 pontos |
| 06-11-21 19:30 | 06-11-21 19:30 | Karlsruher SC | Hamburgo SV | 1:1 | 2 - 4 pontos |
| 07-11-21 12:30 | 07-11-21 12:30 | Erzgebirge Aue | 1. FC Heidenheim 1846 | 2:0 | 2 - 4 pontos |
| 07-11-21 12:30 | 07-11-21 12:30 | FC Schalke 04 | SV Darmstadt 98 | 2:4 | 2 - 4 pontos |
| 24-11-21 17:30 | 24-11-21 17:30 | FC St. Pauli | SV Sandhausen | 3:1 | 2 - 4 pontos |