Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 29-10-21 17:30 | 29-10-21 17:30 | SV Darmstadt 98 | 1. FC Nuremberga | 2:0 | 2 - 4 pontos |
| 29-10-21 17:30 | 29-10-21 17:30 | 1. FC Heidenheim 1846 | FC Schalke 04 | 1:0 | 2 - 4 pontos |
| 30-10-21 12:30 | 30-10-21 12:30 | Werder Bremen | FC St. Pauli | 1:1 | 2 - 4 pontos |
| 30-10-21 12:30 | 30-10-21 12:30 | Hannover 96 | Erzgebirge Aue | 1:1 | 2 - 4 pontos |
| 30-10-21 12:30 | 30-10-21 12:30 | Dynamo Dresden | SV Sandhausen | 0:1 | 2 - 4 pontos |
| 30-10-21 19:30 | 30-10-21 19:30 | Hamburgo SV | Holstein Kiel | 1:1 | 2 - 4 pontos |
| 31-10-21 12:30 | 31-10-21 12:30 | Karlsruher SC | SC Paderborn 07 | 2:4 | 2 - 4 pontos |
| 31-10-21 12:30 | 31-10-21 12:30 | FC Hansa Rostock | Fortuna Düsseldorf | 2:1 | 2 - 4 pontos |
| 31-10-21 12:30 | 31-10-21 12:30 | FC Ingolstadt | Jahn Regensburg | 0:3 | 2 - 4 pontos |