Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 15-10-21 17:30 | 15-10-21 17:30 | SC Paderborn 07 | Jahn Regensburg | 1:1 | 2 - 4 pontos |
| 15-10-21 17:30 | 15-10-21 17:30 | Hannover 96 | FC Schalke 04 | 0:1 | 2 - 4 pontos |
| 16-10-21 12:30 | 16-10-21 12:30 | 1. FC Heidenheim 1846 | FC St. Pauli | 2:4 | 2 - 4 pontos |
| 16-10-21 12:30 | 16-10-21 12:30 | FC Ingolstadt | Holstein Kiel | 1:1 | 2 - 4 pontos |
| 16-10-21 12:30 | 16-10-21 12:30 | Karlsruher SC | Erzgebirge Aue | 2:1 | 2 - 4 pontos |
| 16-10-21 19:30 | 16-10-21 19:30 | Hamburgo SV | Fortuna Düsseldorf | 1:1 | 2 - 4 pontos |
| 17-10-21 12:30 | 17-10-21 12:30 | SV Darmstadt 98 | Werder Bremen | 3:0 | 2 - 4 pontos |
| 17-10-21 12:30 | 17-10-21 12:30 | Dynamo Dresden | 1. FC Nuremberga | 0:1 | 2 - 4 pontos |
| 17-10-21 12:30 | 17-10-21 12:30 | FC Hansa Rostock | SV Sandhausen | 1:1 | 2 - 4 pontos |