Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 16-10-21 17:30 | 16-10-21 17:30 | UD Levante | FC Getafe | 0:0 | 4 - 4 - 6 |
| 16-10-21 20:00 | 16-10-21 20:00 | Real Sociedad | RCD Mallorca | 1:0 | 3 - 6 - 6 |
| 17-10-21 13:00 | 17-10-21 13:00 | Rayo Vallecano | FC Elche | 2:1 | 3 - 6 - 6 |
| 17-10-21 15:15 | 17-10-21 15:15 | Celta Vigo | FC Sevilla | 0:1 | 6 - 6 - 3 |
| 17-10-21 17:30 | 17-10-21 17:30 | FC Villarreal | CA Osasuna | 1:2 | 3 - 6 - 6 |
| 17-10-21 20:00 | 17-10-21 20:00 | FC Barcelona | FC Valencia | 3:1 | 3 - 5 - 6 |
| 18-10-21 18:00 | 18-10-21 18:00 | Deportivo Alavés | Real Betis Sevilla | 0:1 | 4 - 6 - 4 |
| 18-10-21 20:00 | 18-10-21 20:00 | Espanyol Barcelona | FC Cádiz | 2:0 | 3 - 4 - 6 |
| 01-12-21 20:00 | 01-12-21 20:00 | Real Madrid | Athletic Bilbao | 1:0 | 3 - 6 - 6 |
| 22-12-21 18:00 | 22-12-21 18:00 | FC Granada | Atlético Madrid | 2:1 | 6 - 6 - 3 |