Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 21-09-21 18:30 | 21-09-21 18:30 | FC Getafe | Atlético Madrid | 1:2 | 6 - 6 - 3 |
| 21-09-21 21:00 | 21-09-21 21:00 | Athletic Bilbao | Rayo Vallecano | 1:2 | 3 - 6 - 6 |
| 21-09-21 21:00 | 21-09-21 21:00 | UD Levante | Celta Vigo | 0:2 | 4 - 4 - 6 |
| 22-09-21 18:30 | 22-09-21 18:30 | Espanyol Barcelona | Deportivo Alavés | 1:0 | 3 - 5 - 6 |
| 22-09-21 18:30 | 22-09-21 18:30 | FC Sevilla | FC Valencia | 3:1 | 3 - 6 - 6 |
| 22-09-21 21:00 | 22-09-21 21:00 | Real Madrid | RCD Mallorca | 6:1 | 3 - 6 - 6 |
| 22-09-21 21:00 | 22-09-21 21:00 | FC Villarreal | FC Elche | 4:1 | 3 - 6 - 6 |
| 23-09-21 18:30 | 23-09-21 18:30 | FC Granada | Real Sociedad | 2:3 | 6 - 4 - 3 |
| 23-09-21 18:30 | 23-09-21 18:30 | CA Osasuna | Real Betis Sevilla | 1:3 | 4 - 4 - 4 |
| 23-09-21 21:00 | 23-09-21 21:00 | FC Cádiz | FC Barcelona | 0:0 | 6 - 6 - 3 |