Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 25-02-22 20:00 | 25-02-22 20:00 | UD Levante | FC Elche | 3:0 | 3 - 6 - 5 |
| 26-02-22 13:00 | 26-02-22 13:00 | RCD Mallorca | FC Valencia | 0:1 | 6 - 5 - 3 |
| 26-02-22 15:15 | 26-02-22 15:15 | FC Getafe | Deportivo Alavés | 2:2 | 3 - 6 - 6 |
| 26-02-22 17:30 | 26-02-22 17:30 | Rayo Vallecano | Real Madrid | 0:1 | 6 - 6 - 3 |
| 26-02-22 20:00 | 26-02-22 20:00 | Atlético Madrid | Celta Vigo | 2:0 | 3 - 6 - 6 |
| 27-02-22 13:00 | 27-02-22 13:00 | FC Villarreal | Espanyol Barcelona | 5:1 | 3 - 6 - 6 |
| 27-02-22 15:15 | 27-02-22 15:15 | FC Sevilla | Real Betis Sevilla | 2:1 | 3 - 4 - 6 |
| 27-02-22 17:30 | 27-02-22 17:30 | Real Sociedad | CA Osasuna | 1:0 | 3 - 6 - 6 |
| 27-02-22 20:00 | 27-02-22 20:00 | FC Barcelona | Athletic Bilbao | 4:0 | 3 - 6 - 6 |
| 28-02-22 20:00 | 28-02-22 20:00 | FC Granada | FC Cádiz | 0:0 | 3 - 4 - 6 |