Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 04-02-22 20:00 | 04-02-22 20:00 | FC Getafe | UD Levante | 3:0 | 4 - 5 - 4 |
| 05-02-22 13:00 | 05-02-22 13:00 | FC Elche | Deportivo Alavés | 3:1 | 3 - 5 - 6 |
| 05-02-22 15:15 | 05-02-22 15:15 | RCD Mallorca | FC Cádiz | 2:1 | 4 - 4 - 6 |
| 05-02-22 17:30 | 05-02-22 17:30 | Celta Vigo | Rayo Vallecano | 2:0 | 3 - 6 - 5 |
| 05-02-22 20:00 | 05-02-22 20:00 | CA Osasuna | FC Sevilla | 0:0 | 6 - 6 - 3 |
| 06-02-22 13:00 | 06-02-22 13:00 | FC Valencia | Real Sociedad | 0:0 | 4 - 4 - 6 |
| 06-02-22 15:15 | 06-02-22 15:15 | FC Barcelona | Atlético Madrid | 4:2 | 5 - 5 - 4 |
| 06-02-22 17:30 | 06-02-22 17:30 | Real Betis Sevilla | FC Villarreal | 0:2 | 3 - 6 - 6 |
| 06-02-22 20:00 | 06-02-22 20:00 | Real Madrid | FC Granada | 1:0 | 3 - 6 - 6 |
| 07-02-22 20:00 | 07-02-22 20:00 | Athletic Bilbao | Espanyol Barcelona | 2:1 | 3 - 6 - 6 |