Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 17-12-21 20:00 | 17-12-21 20:00 | Celta Vigo | Espanyol Barcelona | 3:1 | 3 - 4 - 6 |
| 18-12-21 13:00 | 18-12-21 13:00 | Rayo Vallecano | Deportivo Alavés | 2:0 | 3 - 6 - 6 |
| 18-12-21 15:15 | 18-12-21 15:15 | Real Sociedad | FC Villarreal | 1:3 | 3 - 5 - 6 |
| 18-12-21 17:30 | 18-12-21 17:30 | FC Barcelona | FC Elche | 3:2 | 3 - 6 - 6 |
| 18-12-21 20:00 | 18-12-21 20:00 | FC Sevilla | Atlético Madrid | 2:1 | 4 - 4 - 6 |
| 19-12-21 13:00 | 19-12-21 13:00 | FC Granada | RCD Mallorca | 4:1 | 4 - 5 - 4 |
| 19-12-21 15:15 | 19-12-21 15:15 | Athletic Bilbao | Real Betis Sevilla | 3:2 | 5 - 5 - 3 |
| 19-12-21 17:30 | 19-12-21 17:30 | FC Getafe | CA Osasuna | 1:0 | 4 - 5 - 4 |
| 19-12-21 20:00 | 19-12-21 20:00 | Real Madrid | FC Cádiz | 0:0 | 3 - 6 - 6 |
| 20-12-21 20:00 | 20-12-21 20:00 | UD Levante | FC Valencia | 3:4 | 4 - 6 - 3 |