Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 19-11-21 20:00 | 19-11-21 20:00 | UD Levante | Athletic Bilbao | 0:0 | 6 - 6 - 3 |
| 20-11-21 13:00 | 20-11-21 13:00 | Celta Vigo | FC Villarreal | 1:1 | 4 - 4 - 6 |
| 20-11-21 15:15 | 20-11-21 15:15 | FC Sevilla | Deportivo Alavés | 2:2 | 3 - 6 - 6 |
| 20-11-21 17:30 | 20-11-21 17:30 | Atlético Madrid | CA Osasuna | 1:0 | 3 - 6 - 6 |
| 20-11-21 20:00 | 20-11-21 20:00 | FC Barcelona | Espanyol Barcelona | 1:0 | 3 - 6 - 6 |
| 21-11-21 13:00 | 21-11-21 13:00 | FC Getafe | FC Cádiz | 4:0 | 5 - 4 - 4 |
| 21-11-21 15:15 | 21-11-21 15:15 | FC Granada | Real Madrid | 1:4 | 6 - 6 - 3 |
| 21-11-21 17:30 | 21-11-21 17:30 | FC Elche | Real Betis Sevilla | 0:3 | 4 - 6 - 3 |
| 21-11-21 20:00 | 21-11-21 20:00 | Real Sociedad | FC Valencia | 0:0 | 3 - 6 - 6 |
| 22-11-21 20:00 | 22-11-21 20:00 | Rayo Vallecano | RCD Mallorca | 3:1 | 3 - 5 - 6 |