| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 13-02-25 17:45 | Royale Union Saint-Gilloise | Ajax Amsterdão | 0:2 |
| 13-02-25 17:45 | Fenerbahce Istambul | RSC Anderlecht | 3:0 |
| 13-02-25 17:45 | FC Midtjylland | Real Sociedad | 1:2 |
| 13-02-25 17:45 | Ferencvaros Budapest | Viktoria Plzeň | 1:0 |
| 13-02-25 20:00 | FC Porto | AS Roma | 1:1 |
| 13-02-25 20:00 | PAOK Salónica | FCSB Bukarest | 1:2 |
| 13-02-25 20:00 | AZ Alkmaar | Galatasaray Istambul | 4:1 |
| 13-02-25 20:00 | FC Twente Enschede | FK Bodö/Glimt | 2:1 |