| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 30-01-25 20:00 | FCSB Bukarest | Manchester United | 0:2 |
| 30-01-25 20:00 | RSC Anderlecht | 1899 Hoffenheim | 3:4 |
| 30-01-25 20:00 | Athletic Bilbao | Viktoria Plzeň | 3:1 |
| 30-01-25 20:00 | OGC Nice | FK Bodö/Glimt | 1:1 |
| 30-01-25 20:00 | Olympique Lyon | PFC Ludogorets Razgrad | 1:1 |
| 30-01-25 20:00 | FC Midtjylland | Fenerbahce Istambul | 2:2 |
| 30-01-25 20:00 | Dínamo Kiev | Rigas Futbola Skola | 1:0 |
| 30-01-25 20:00 | FC Twente Enschede | Besiktas Istambul | 1:0 |
| 30-01-25 20:00 | AS Roma | Eintracht Frankfurt | 2:0 |
| 30-01-25 20:00 | Glasgow Rangers | Royale Union Saint-Gilloise | 2:1 |
| 30-01-25 20:00 | Slavia Praga | Malmö FF | 2:2 |
| 30-01-25 20:00 | Tottenham Hotspurs | IF Elfsborg Boras | 3:0 |
| 30-01-25 20:00 | Maccabi Tel Avive | FC Porto | 0:1 |
| 30-01-25 20:00 | Ajax Amsterdão | Galatasaray Istambul | 2:1 |
| 30-01-25 20:00 | Ferencvaros Budapest | AZ Alkmaar | 4:3 |
| 30-01-25 20:00 | Sporting Braga | Lazio Roma | 1:0 |
| 30-01-25 20:00 | Olympiakos Pireu | Qarabag | 3:0 |
| 30-01-25 20:00 | Real Sociedad | PAOK Salónica | 2:0 |