| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 28-11-24 17:45 | Lazio Roma | PFC Ludogorets Razgrad | 0:0 |
| 28-11-24 17:45 | Dínamo Kiev | Viktoria Plzeň | 1:2 |
| 28-11-24 17:45 | Qarabag | Olympique Lyon | 1:4 |
| 28-11-24 17:45 | Besiktas Istambul | Maccabi Tel Avive | 1:3 |
| 28-11-24 17:45 | Rigas Futbola Skola | PAOK Salónica | 0:2 |
| 28-11-24 17:45 | RSC Anderlecht | FC Porto | 2:2 |
| 28-11-24 17:45 | Athletic Bilbao | IF Elfsborg Boras | 3:0 |
| 28-11-24 17:45 | AZ Alkmaar | Galatasaray Istambul | 1:1 |
| 28-11-24 20:00 | Slavia Praga | Fenerbahce Istambul | 1:2 |
| 28-11-24 20:00 | Manchester United | FK Bodö/Glimt | 3:2 |
| 28-11-24 20:00 | Tottenham Hotspurs | AS Roma | 2:2 |
| 28-11-24 20:00 | Ferencvaros Budapest | Malmö FF | 4:1 |
| 28-11-24 20:00 | Sporting Braga | 1899 Hoffenheim | 3:0 |
| 28-11-24 20:00 | Real Sociedad | Ajax Amsterdão | 2:0 |
| 28-11-24 20:00 | FC Midtjylland | Eintracht Frankfurt | 1:2 |
| 28-11-24 20:00 | FCSB Bukarest | Olympiakos Pireu | 0:0 |
| 28-11-24 20:00 | OGC Nice | Glasgow Rangers | 1:4 |
| 28-11-24 20:00 | FC Twente Enschede | Royale Union Saint-Gilloise | 0:1 |