| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 17-03-22 17:45 | Estrela Vermelha Belgrado | Glasgow Rangers | 2:1 |
| 17-03-22 17:45 | Galatasaray Istambul | FC Barcelona | 1:2 |
| 17-03-22 17:45 | AS Mónaco | Sporting Braga | 1:1 |
| 17-03-22 17:45 | Bayer 04 Leverkusen | Atalanta Bergamo | 0:1 |
| 17-03-22 20:00 | West Ham United | FC Sevilla | 2:0a.p. |
| 17-03-22 20:00 | Olympique Lyon | FC Porto | 1:1 |
| 17-03-22 20:00 | Eintracht Frankfurt | Real Betis Sevilla | 1:1a.p. |