| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 25-09-24 17:45 | AZ Alkmaar | IF Elfsborg Boras | 3:2 |
| 25-09-24 17:45 | FK Bodö/Glimt | FC Porto | 3:2 |
| 25-09-24 20:00 | RSC Anderlecht | Ferencvaros Budapest | 2:1 |
| 25-09-24 20:00 | OGC Nice | Real Sociedad | 1:1 |
| 25-09-24 20:00 | PFC Ludogorets Razgrad | Slavia Praga | 0:2 |
| 25-09-24 20:00 | Galatasaray Istambul | PAOK Salónica | 3:1 |
| 25-09-24 20:00 | FC Midtjylland | 1899 Hoffenheim | 1:1 |
| 25-09-24 20:00 | Dínamo Kiev | Lazio Roma | 0:3 |
| 25-09-24 20:00 | Manchester United | FC Twente Enschede | 1:1 |
| 26-09-24 17:45 | Malmö FF | Glasgow Rangers | 0:2 |
| 26-09-24 17:45 | Fenerbahce Istambul | Royale Union Saint-Gilloise | 2:1 |
| 26-09-24 20:00 | FCSB Bukarest | Rigas Futbola Skola | 4:1 |
| 26-09-24 20:00 | Olympique Lyon | Olympiakos Pireu | 2:0 |
| 26-09-24 20:00 | AS Roma | Athletic Bilbao | 1:1 |
| 26-09-24 20:00 | Eintracht Frankfurt | Viktoria Plzeň | 3:3 |
| 26-09-24 20:00 | Ajax Amsterdão | Besiktas Istambul | 4:0 |
| 26-09-24 20:00 | Sporting Braga | Maccabi Tel Avive | 2:1 |
| 26-09-24 20:35 | Tottenham Hotspurs | Qarabag | 3:0 |