Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 27-08-21 19:30 | 27-08-21 19:30 | Borussia Dortmund | 1899 Hoffenheim | 3:2 | 2 - 8 - 8 |
| 28-08-21 14:30 | 28-08-21 14:30 | FC Augsburg | Bayer 04 Leverkusen | 1:4 | 8 - 6 - 2 |
| 28-08-21 14:30 | 28-08-21 14:30 | FSV Mainz 05 | SpVgg Greuther Fürth | 3:0 | 2 - 6 - 8 |
| 28-08-21 14:30 | 28-08-21 14:30 | VfB Estugarda | SC Friburgo | 2:3 | 3 - 3 - 5 |
| 28-08-21 14:30 | 28-08-21 14:30 | 1. FC Colónia | VfL Bochum | 2:1 | 3 - 5 - 6 |
| 28-08-21 14:30 | 28-08-21 14:30 | Arminia Bielefeld | Eintracht Frankfurt | 1:1 | 6 - 4 - 3 |
| 28-08-21 17:30 | 28-08-21 17:30 | FC Bayern Munique | Hertha BSC Berlim | 5:0 | 2 - 8 - 8 |
| 29-08-21 14:30 | 29-08-21 14:30 | 1. FC Union Berlim | Bor. Mönchengladbach | 2:1 | 4 - 4 - 3 |
| 29-08-21 16:30 | 29-08-21 16:30 | VfL Wolfsburgo | RB Leipzig | 1:0 | 6 - 4 - 3 |