Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 18-02-22 19:30 | 18-02-22 19:30 | FSV Mainz 05 | Bayer 04 Leverkusen | 3:2 | 6 - 8 - 2 |
| 19-02-22 14:30 | 19-02-22 14:30 | FC Augsburg | SC Friburgo | 1:2 | 5 - 4 - 3 |
| 19-02-22 14:30 | 19-02-22 14:30 | VfB Estugarda | VfL Bochum | 1:1 | 3 - 3 - 5 |
| 19-02-22 14:30 | 19-02-22 14:30 | VfL Wolfsburgo | 1899 Hoffenheim | 1:2 | 3 - 4 - 4 |
| 19-02-22 14:30 | 19-02-22 14:30 | Arminia Bielefeld | 1. FC Union Berlim | 1:0 | 4 - 4 - 3 |
| 19-02-22 17:30 | 19-02-22 17:30 | 1. FC Colónia | Eintracht Frankfurt | 1:0 | 3 - 4 - 4 |
| 20-02-22 14:30 | 20-02-22 14:30 | FC Bayern Munique | SpVgg Greuther Fürth | 4:1 | 2 - 8 - 8 |
| 20-02-22 16:30 | 20-02-22 16:30 | Borussia Dortmund | Bor. Mönchengladbach | 6:0 | 2 - 6 - 7 |
| 20-02-22 18:30 | 20-02-22 18:30 | Hertha BSC Berlim | RB Leipzig | 1:6 | 8 - 8 - 2 |