Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 21-01-22 19:30 | 21-01-22 19:30 | Eintracht Frankfurt | Arminia Bielefeld | 0:2 | 2 - 7 - 8 |
| 22-01-22 14:30 | 22-01-22 14:30 | Bor. Mönchengladbach | 1. FC Union Berlim | 1:2 | 3 - 4 - 4 |
| 22-01-22 14:30 | 22-01-22 14:30 | Bayer 04 Leverkusen | FC Augsburg | 5:1 | 2 - 8 - 8 |
| 22-01-22 14:30 | 22-01-22 14:30 | 1899 Hoffenheim | Borussia Dortmund | 2:3 | 6 - 5 - 3 |
| 22-01-22 14:30 | 22-01-22 14:30 | SC Friburgo | VfB Estugarda | 2:0 | 2 - 7 - 8 |
| 22-01-22 14:30 | 22-01-22 14:30 | SpVgg Greuther Fürth | FSV Mainz 05 | 2:1 | 7 - 6 - 2 |
| 22-01-22 17:30 | 22-01-22 17:30 | VfL Bochum | 1. FC Colónia | 2:2 | 5 - 3 - 3 |
| 23-01-22 14:30 | 23-01-22 14:30 | RB Leipzig | VfL Wolfsburgo | 2:0 | 2 - 8 - 8 |
| 23-01-22 16:30 | 23-01-22 16:30 | Hertha BSC Berlim | FC Bayern Munique | 1:4 | 8 - 8 - 2 |