Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 17-12-21 19:30 | 17-12-21 19:30 | FC Bayern Munique | VfL Wolfsburgo | 4:0 | 2 - 8 - 8 |
| 18-12-21 14:30 | 18-12-21 14:30 | 1899 Hoffenheim | Bor. Mönchengladbach | 1:1 | 3 - 5 - 5 |
| 18-12-21 14:30 | 18-12-21 14:30 | Eintracht Frankfurt | FSV Mainz 05 | 1:0 | 3 - 4 - 5 |
| 18-12-21 14:30 | 18-12-21 14:30 | RB Leipzig | Arminia Bielefeld | 0:2 | 2 - 8 - 8 |
| 18-12-21 14:30 | 18-12-21 14:30 | SpVgg Greuther Fürth | FC Augsburg | 0:0 | 5 - 4 - 3 |
| 18-12-21 14:30 | 18-12-21 14:30 | VfL Bochum | 1. FC Union Berlim | 0:1 | 4 - 4 - 3 |
| 18-12-21 17:30 | 18-12-21 17:30 | Hertha BSC Berlim | Borussia Dortmund | 3:2 | 8 - 7 - 2 |
| 19-12-21 14:30 | 19-12-21 14:30 | SC Friburgo | Bayer 04 Leverkusen | 2:1 | 4 - 4 - 4 |
| 19-12-21 16:30 | 19-12-21 16:30 | 1. FC Colónia | VfB Estugarda | 1:0 | 3 - 5 - 5 |