Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 10-12-21 19:30 | 10-12-21 19:30 | 1. FC Colónia | FC Augsburg | 0:2 | 2 - 6 - 8 |
| 11-12-21 14:30 | 11-12-21 14:30 | RB Leipzig | Bor. Mönchengladbach | 4:1 | 2 - 6 - 8 |
| 11-12-21 14:30 | 11-12-21 14:30 | FC Bayern Munique | FSV Mainz 05 | 2:1 | 2 - 8 - 8 |
| 11-12-21 14:30 | 11-12-21 14:30 | VfL Bochum | Borussia Dortmund | 1:1 | 8 - 8 - 2 |
| 11-12-21 14:30 | 11-12-21 14:30 | Hertha BSC Berlim | Arminia Bielefeld | 2:0 | 2 - 5 - 7 |
| 11-12-21 14:30 | 11-12-21 14:30 | SC Friburgo | 1899 Hoffenheim | 1:2 | 3 - 4 - 5 |
| 11-12-21 17:30 | 11-12-21 17:30 | VfL Wolfsburgo | VfB Estugarda | 0:2 | 3 - 4 - 7 |
| 12-12-21 14:30 | 12-12-21 14:30 | SpVgg Greuther Fürth | 1. FC Union Berlim | 1:0 | 8 - 8 - 2 |
| 12-12-21 16:30 | 12-12-21 16:30 | Eintracht Frankfurt | Bayer 04 Leverkusen | 5:2 | 5 - 5 - 3 |